With the upcoming Trulicity CVOT (REWIND) presentation at ADA 2019 (Sunday, June 9 at 4:30-6:30 pm PT), and in the context of the other GLP-1RA CVOTs (particularly LEADER, SUSTAIN 6, PIONEER 6, and HARMONY), the FENIX team is decidedly split on how positive the REWIND results will be. Below, FENIX presents Matt’s bold prediction for a hit on all-cause mortality vs. the team’s more moderate consensus of a LEADER-like ~13% RRR with a potential miss in the primary prevention cohort.